Coronary heart disease (CHD) is the leading cause of death in the United States Coronary Heart Disease. CHD is a complex, multi-step disease caused by an interplay between genetic and lifestyle factors, such as diet, smoking and being sedentary. A significant percentage of CHD cases are caused by diseases related to a single gene. Knowing your genetics can help identify rish of developing CHD the most effective intervention.
Genetic Testing Provides:
Otogenetics worked with GBInsight to develop this Coronary Heart Disease Gene Panel, and we want you to have the information you need to understand genes involved with CHD once the test is completed. The most common causes of familial combined hyperlipidemia (FCHL) and familial hypercholesterolemia (FH) are included in the panel, as well as genetic determinates of Lipoprotein(a) or Lp(a) levels and rare genetic variants underlying lipid disorders that increase the risk for CHD. Over one hundred genes associated with these various pathways that contribute to CHD are examined, giving you the comprehensive results needed to understand the risk for CHD as well as the best methods for intervention.
Our Next Generation Sequencing (NGS) techniques eliminate ambiguities at every locus compared to other genetic testing methods, giving more accurate results.
The Coronary Heart Disease Gene Panel is currently offered for research use. Researchers and clinicians can order the tests for clinical investigation purposes. This test will help clinicians identify the potential genetic etiology of Coronary Heart Disease and help them design more targeted and effective interventions.
c10orf107, C6orf10, CBS, CD36, CDKN2A, CELSR2, CETP, CNNM2, COMT, CPS1, CRP, CSK, CX3CR1, CYP11B2, CYP17A1, CYP1A2, CYP3A5
FADS1, FAIM2, FGA, FGF5, FGG, FTO
HCP5, HFE, HLA-DQA1, HLA-DQB2, HLA-DRB1, HMGCR, HNF1A, HNF4A, HP, HTR2C
IL12B, IL1A, IL21, IL23R, IL6, IL6R, INSIG2, IRF5, IRS1, ITGAM, ITGAX, ITGB3, ITIH4
MC4R, MICB, MMP3, MSH5, MTHFR, MTR, MTRR
NAA25, NINJ2, NOS3, NOTCH4, NRXN3
PALLD, PCSK9, PEMT, PHACTR1, PLA2G7, PON1, PPARA, PPARD, PPARG, PSRC1, PTPN11, PTPN22
SCARB1, SEC16B, SELP, SH2B3, SHMT1, SLC22A3, SLC39A8, SOD3, STAP1, STAT4, SVEP1
TFAP2B, TMEM258, TNF, TNFAIP3, TNPO3, TNXB, TOMM40, TRI-AAT7-2, TYK2