Nutrition Genetics Gene Testing

Our Nutrition Genetics Gene Testing is a next generation sequencing panel that simultaneously examines over 600 genes to understand the genetic architecture preventable metabolic-related diseases.

Otogenetics' Nutrition Genetics Gene Testing can help identify the risk of developing preventable metabolic-related diseases and most effective intervention.

Certain genes affect how different foods and nutrients are metabolized. Additionally, many of today's health problems are "diet-induced." By combining gene-diet-disease interactions, the genes on this panel examine variants that may be risk-factors which can be potentially avoided by nutrition management.

Categories covered by this testing:

  • High blood cholesterol is one of the major risk factors for heart disease. Genetic variations may predispose people to different levels of blood cholesterol in response to dietary fat.  One variant of the APOE gene makes a protein with slower cholesterol metabolism, which results in a lower blood cholesterol. In contrast, another variant makes a protein characterized by faster cholesterol metabolism resulting in a higher blood cholesterol level. Since high fat diets often lead to high cholesterol, low-fat, high-carb diets are often recommended for the first variant type while high-fat, low-carb diets are typically recommended for the latter.
  • Diabetes increases the risk for heart disease, as well as other complications including stroke, kidney failure, ulcers, and eye damage. Numerous genes have been identified that confer impairment in insulin secretion and utilization, and alteration of glucose and lipid homeostasis. Diabetes risk can be minimized by choosing the right food and lifestyle options that are based on genetic makeup.
  • Obesity also increases the risk of heart disease, diabetes and high blood pressure. The major driving force behind obesity is overeating, which is largely due to genes that are responsible for appetite (desire to eat) and satiety (sensation of fullness) regulation. Emotional eating and low metabolism also play a role. Risk for excess weight gain can be minimized by adopting a personalized regimen that is compatible with genetic risk variants.
  • Cardiovascular diseases are complex and caused by multiple factors. Understanding genetic variations can help assess individual risk factors to help take preventative lifestyle changes against coronary heart disease.

Why choose Otogenetics Nutrition Panel for testing?

Otogenetics Corporation worked with GB HealthWatch to develop this Nutrition Genetics (NG) Panel for preventable metabolic-related diseases, which sequences 638 genes known to be associated with genes related to metabolic diseases.

State of the Art NGS Technique

Our Next Generation Sequencing (NGS) techniques eliminate ambiguities at every locus compared to other genetic testing methods, giving more accurate results.

Reporting Options



The Nutrition Gene Panel is currently offered for research use. Researchers and clinicians can order the tests for clinical investigation purposes. This nutrition gene panel test will help identify the potential genetic etiology of metabolic diseases and help design more targeted and effective interventions.

Reports Include:

  • Genetic variants called from NGS
  • Pathogenic/likely pathogenic mutations previously reported in the ClinVar database and literatures
  • Novel variants that are in silicon predicated as high impact to the disease.
  • Pathway ranked genetic risk scores

638 Genes Sampled

AADAT, ABCA1, ABCA7, ABCB1, ABCC11, ABCC8, ABCG1, ABCG2, ABCG8, ABO, ACADL, ACADS, ACE, ACKR1, ADCY3, ADCY5, ADD1, ADH1B, ADH1C, ADH4, ADIPOQ, ADORA2A, ADRA2A, ADRB1, ADRB2, ADRB3, AGER, AGPAT1, AGRP, AGT, AGTR1, AKAP10, AKR1B1, AKT2, ALDH1A2, ALDH2, ALDOB, ALOX5, ALPL, ANGPTL4, ANK3, ANKK1, APOA1, APOA2, APOA4, APOA5, APOB, APOC1, APOC2, APOC3, APOE, APPL1, APRT, AR, ARAP1, ARHGAP24, ATG16L1, ATM, ATP2B1, ATXN2, ATXN2L
B4GALT6, BACH2, BAG6, BCAS3, BCDIN3D, BCL11A, BCMO1, BDNF, BHMT, BLK, BMP2, BOD1, BSN, BTNL2, BUD13
c10orf107, C11orf65, C13orf31, C2, C21orf33, C2CD4A, C5orf56, C6orf10, c9orf3, C9orf7, CADM2, CAPN10, CAPZA1, CAPZB, CARD9, CARS, CARTPT, CASC15, CASC17, CASC8, CASR, CASZ1, CAT, CAV1, CBLN4, CBS, CCAT2, CCDC170, CCHCR1, CCKAR, CCL2, CCL4L2, CCR3, CD320, CD36, CDH13, CDHR5, CDK10, CDK5RAP1, CDKAL1, CDKN2A, CDKN2B, CEL, CELSR2, CES1, CETP, CFB, CFH, CGREF1, CH25H, CHRM2, CHRNA3, CHRNA5, CLDN14, CLEC16A, CLEC2D, CLMN, CLN3, CLOCK, CNNM2, CNR1, COBLL1, COL1A1, COL1A2, COLEC10, COMT, CPE, CPS1, CPT2, CR1, CRP, CRY2, CSK, CTLA4, CTNNBL1, CUBN, CX3CR1, CYB5R3, CYP11B2, CYP17A1, CYP1A2, CYP26B1, CYP27B1, CYP2C19, CYP2C9, CYP2D6, CYP2R1, CYP3A5, CYP4F2
DAB2, DAP, DCAKD, DENND1A, DGKB, DGKG, DIO1, DIO2, DIP2C, DIRC3, DLG5, DMGDH, DOCK7, DPEP1, DPYSL5, DRD2, DUSP9, DYRK1B
ECM1, EDAR, ELOVL2, ENPEP, ENPP1, EPDR1, EPHX1, EPHX2, EPO, ERAP2, ERBB3, ERBB4, ESR1, ETFDH, EXOC2
FAAH, FABP2, FABP4, FADS1, FADS2, FAIM2, FANCL, FES, FFAR4, FGA, FGF5, FGF7, FGFR1OP, FGFR1OP2P1, FGFR2, FGG, FIGN, FLG2, FOXA2, FOXE1, FOXO3, FPGT-TNNI3K, FSHB, FSHR, FTO, FUT2
G6PC2, G6PD, GABRA2, GC, GCGR, GCK, GCKR, GGCX, GHRL, GIF, GJA4, GLIS3, GLUD1, GNA12, GNAS GNB3, GNPDA2, GOT1, GPD2, GPIHBP1, GPR65, GPRC5B, GPX1, GREM1, GRK5, GSDMB, GSTM1, GSTP1, GSTT1
H6PD, HBD, HBG1, HBG2, HCP5, HECW1, HERC2, HFE, HHEX, HIST1H2BJ, HLA-DPA1, HLA-DQA1, HLA-, QB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB5, HMGA1, HMGCR, HNF1A, HNF1B, HNF4A, HORMAD2, HP, HSD11B1, HSD11B2, HTR2C, HYKK
IFNG, IFNL4, IGF1, IGF2, IGF2BP2, IGFBP2, IGFBP3, IL10, IL10RA, IL10RB, IL12A, IL12A-AS1, IL12B, IL12RB2, IL18R1, IL18RAP, IL1A, IL1B, IL1R2, IL2, IL21, IL23R, IL27, IL2RA, IL2RB, IL33, IL6, IL6R, INADL, INS, INSIG2, INSR, IREB2, IRF5, IRGM, IRS1, IRS2, ITGAM, ITGAX, ITGB3, ITIH4
JAK2
KALRN, KCNJ11, KCNK3, KCNQ1, KCTD15, KDM5D, KIAA1109, KLF11, KLF12, KRR1, KRT8, KSR2

LDLR, LDLRAP1, LEP, LEPR, LGR5, LHCGR, LHX3, LINC00598, LINC00994, LINC01432, LINGO1, LINGO2, LIPA, LIPC, LIPF, LIPG, LIPI, LMF1, LOC102606465, LOC284930, LPA, LPL, LPP, LRP1B, LRP5, LRP6, LRRC32, LY6G6C, LY6G6F
MADD, MAF, MAML2, MAN2A1, MAOA, MAP2K5, MAPK8IP1, MBIP, MBL2, MC1R, MC3R, MC4R, MCHR1, MCM6, MEIS1, MICA, MICB, MIR6774, MMAA, MMP1, MMP3, MRAP2, MROH2A, MROH3P, MRPS35P3, MSH5, MSMB, MST1, MTCH2, MTHFD1, MTHFD1L, MTHFR, MTIF3, MTNR1B, MTR, MTRR, MTTP, MUC1, MUT, MYEOV, MYLK
NAA25, NAMPT, NAT2, NAT8, NBPF3, NCAN, NCOA6, NEGR1, NEUROD1, NINJ2, NKX2-3, NOD2, NOS3, NOTCH4, NOX4, NPC1, NPR3, NPY, NQO1, NR0B2, NR1D1, NR5A1, NRIP1, NRXN3, NT5C2, NTRK2, NUDT11, NUDT3, NXPE1
OAS1, OPRM1, OR4S1, OSR1, OTUD3
PALLD, PAX4, PCDH15, PCSK1, PCSK9, PDE10A, PDE3A, PDE8B, PDGFB, PDX1, PECR, PEMT, PER2, PHACTR1, PHLDA1, PIGU, PKD2L1, PLA2G7, PLCD3, PLCE1, PLEKHA7, PLEKHH2, PNLIPRP2, PNPLA3, POC5, POMC, PON1, PPARA, PPARD, PPARG, PPARGC1A, PPARGC1B, PPP1R3A, PRDM6, PRKAG2, PRKAG3, PRKCH, PRKD1, PRMT8, PRNCR1, PROX1, PRRC2A, PSORS1C1, PSRC1, PTBP2, PTCSC2, PTER, PTGER4, PTPN1, PTPN11, PTPN2, PTPN22, PUS10, PVRL2, PVT1, PYROXD2, PYY
QPCTL
RAB4B, RAB5B, RAD50, RAD9A, RASGRP1, RBP4, RBPJ, RETN, RFX3, RGS1, RGS14, RIC3, RMST, RNF5, RNLS, RPS3AP51, rs28435578, RTTN
SCAMP3, SCARB1, SCG3, SCN4A, SDC3, SEC16B, SELP, SEPP1, SGPP1, SH2B1, SH2B3, SHBG, SHMT1, SI, SIM1, SIRT1, SKIV2L, SLC16A9, SLC17A1, SLC17A3, SLC22A1, SLC22A12, SLC22A3, SLC22A4, SLC22A5, SLC22A7, SLC23A1, SLC23A2, SLC24A5, SLC2A2, SLC2A4, SLC2A9, SLC30A8, SLC34A3, SLC39A8, SLC44A4, SLC45A2, SLC4A7, SLC6A4, SLCO1B1, SMAD3, SMCO4, SMURF1, SOD2, SOD3, SP140, SPTLC1, SREBF1, STAP1, STAT3, STAT4, STK33, SUMO1P1, SVEP1, SYN2, SYNE1
TAGAP, TAS2R16, TAS2R38, TBC1D4, TBX2, TBX3, TCF4, TCF7L2, TCN1, TCN2, TDP1, TERT, TFAP2B, THADA, TLR1, TMCO1, TMEM174, TMEM18, TMEM229B, TMEM258, TMPRSS6, TNF, TNFAIP3, TNFRSF11B, TNFSF15, TNPO3, TNXB, TOMM40, TP73, TPMT, TRHR, TRI-AAT7-2, TRIM46, TRPM6, TRPV5, TUB, TYK2, TYMS, TYMSOS, TYR
UBE2L3, UCP2, UCP3, UGT1A1, UHRF1BP1, ULK4, UMOD, USF1, USP9Y
VDR, VEGFA, VIMP, VKORC1, WFS1, WIBG, WNT10B, WNT16
YAP1
ZBTB40, ZC3H4, ZGPAT, ZMIZ1, ZNF365, ZNF518B, ZNF608, ZNF652, ZPR1