Research and Discovery

WHOLE EXOME SEQUENCING

Analyzing the complete coding sequences in Human, Mouse, Canine and Zebra Fish

 


Clinical Genetic Testing

GENOMIC MEDICINE

DNA and RNA sequencing to identify the molecular fingerprint of a patient for Precision Medicine

 

Research and Discovery

RNA SEQUENCING

Profiling gene expression to reveal alternative splicing, structural variations and novel transcripts

 


Clinical Genetic Testing

REPRODUCTIVE MEDICINE

Providing parents with meaningful information to guide pregnancy planning 

 

Research and Discovery

CLINICAL TRIALS

Assess drug treatment efficacy and guide healthcare decision making

 


Clinical Genetic Testing

HEREDITARY CANCER RISK ASSESSMENT

 Genetic testing can identify at-risk patients and their family members

 

Research and Discovery

DISEASE GENE TESTING

Comprehensive NGS service for disease associated genes 

 


Clinical Genetic Testing

PHARMACOGENOMICS

Your genetic make-up affects your response to medication.  Personalized medication choices to increase drug efficiency and reduce adverse reactions

 

Research and Discovery

BIOMARKER IDENTIFICATION

Discover potential disease biomarkers

 


Clinical Genetic Testing

  HEARING LOSS & NEWBORN SCREENING 

  Gene testing for better outcomes and language development 

 

Research and Discovery

NUTRITIONAL GENOMICS

Gene-Disease-Diet and risks for obesity, diabetes, cardiovascular diseases 

 


Clinical Genetic Testing

CARDIOMYOPATHY

Identify genetic factors of heart disease in all age groups 

 

Research and Discovery

ADDITIONAL NEXT GENERATION SEQUENCING

Flexible approaches for your NGS projects 

 


Clinical Genetic Testing

CLINICAL EXOME SEQUENCING

Determine novel disease-causing DNA variants 

 

Otogenetics is a CAP-accredited clinical laboratory specialized in Next Generation Sequencing (NGS) based genetic testing and additional molecular genetic diagnosis. Test offering includes Carrier Screening, NIPT, Hereditary Cancer Risk Assessment, Deafness Gene testing, genetic testing for other rare genetic diseases, and clinical Exome sequencing. In addition, Otogenetics participates in clinical trials and offers research services for exome sequencing, targeted panel sequencing, and  RNA Sequencing.

Results from genetic diagnoses and research performed at Otogenetics resulted in publications in highly reputable biomedical journals including Nature and Nature Medicine; attesting to the high caliber and quality of the gene panel design offered by the company.  Otogenetics also assists medical schools in training a new generation of medical students in Precision Medicine.

Publications & Press Releases

Computation Biology Modeling (CBM) Based on NGS Data Provided By Otogenetics for Personalized Treatment of Non-responding Cancer Patients

Physicians, researchers and computation scientists used patient genomic sequencing and CNV data generated by Otogenetics in a clinical trial for identification of effective biological pathway targets unique to each individual cancer patient who had failed traditional treatment(s). The mathematical model…

Somatic activating mutations in MAP2K1 cause melorheostosis

Deep Exome Sequencing by Otogenetics for Clinical Researchers leads to discovery of key somatic mutations in MAP2K1 in melorheostotic* bones of patients. (*Melorheosis is characterized by excess bone formation on the surface of the bone. The bone overgrowth lesions are…

Otogenetics helps clinicians in discovery of a novel autosomal dominant hearing loss mutation

Otogenetics hearing loss gene test lend the tool for clinicians to discover an autosomal dominant hearing loss mutation in POU4F3 gene. This particular variant t cosegregated with hearing loss in family members but was not detected in 580 normal hearing…

Cancer Marker Identification Using Otogenetics NGS Service

Combined mutation in Vhl, Trp53 and Rb1 causes clear cell renal cell carcinoma in mice Read the full article here